It’s been yet another roller coaster of a year in the bioscience industry: lots of excitement, but some real lows, too. PerkinElmer acquired Caliper, but announced layoffs. Pacific Bioscience, a high flyer early in 2011, is perhaps now plummeting to earth: it laid off 130 workers. Even the golden child of life science tools, Illumina, has had sluggish sales and recently announced it will shed 8% of its workforce. Sometimes it’s not easy to hang on, much less enjoy the ride.